Integrating genomics, big data, and computing to drive biological discoveries and medical innovations

Highlighted Publications

Wang Y*, Xie Z*, Kutschera E, Adams JI, Kadash-Edmondson KE, Xing Y. (2024) rMATS-turbo: an efficient and flexible computational tool for alternative splicing analysis of large-scale RNA-seq data. Nature Protocols, 19:1083-1104.

Wang F*, Xu Y*, Wang R*, Zhang B, Smith N, Notaro A, Gaerlan S, Kutschera E, Kadash-Edmondson KE, Xing Y+, Lin L+. (2023) TEQUILA-seq: A versatile and low-cost method for targeted long-read RNA sequencing. Nature Communications, 14:4760.

Pan Y*, Phillips JW*, Zhang BD*, Noguchi M*, Kutschera E, McLaughlin J, Nesterenko PA, Mao Z, Bangayan NJ, Wang R, Tran W, Yang HT, Wang Y, Xu Y, Obusan MB, Cheng D, Lee AH, Kadash-Edmondson KE, Champhekar A, Puig-Saus C, Ribas A, Prins RM, Seet CS, Crooks GM, Witte ON, Xing Y. (2023) IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing. PNAS, 120(21):e2221116120.

Gao Y*, Wang F*, Wang R*, Kutschera E, Xu Y, Xie S, Wang Y, Kadash-Edmondson KE, Lin L, and Xing Y. (2023) ESPRESSO: Robust discovery and quantification of transcript isoforms from error-prone long-read RNA-seq data. Science Advances, 9(3):eabq507.

Xin R*, Gao Y*, Gao Y, Wang R, Kadash-Edmondson KE, Liu B, Wang Y, Lin L, Xing Y. (2021) isoCirc catalogs full-length circular RNA isoforms in human transcriptomes. Nature Communications, 12:266. (*joint first authors)

Find Us

The Xing Lab is located on the 9th floor of the Colket Translational Research Building.

The Children’s Hospital of Philadelphia
9054 Colket Translational Research Bldg.
3501 Civic Center Blvd.
Philadelphia, PA 19104
(215) 590-0280